woe

Synonyms: adversity affliction agony anguish bemoaning blues burden calamity care cataclysm catastrophe curse dejection deploring depression disaster distress dole drag gloom grief grieving hardship headache heartache heartbreak lamentation melancholy misadventure misery misfortune pain rain regret rue sadness sorrow tragedy trial tribulation trouble unhappiness wretchedness

Antonyms: happiness joy