catastrophe

Synonyms: accident adversity affliction alluvion bad luck bad news blow calamity casualty cataclysm contretemps crash culmination curtains debacle denouement desolation devastation disaster emergency end failure fatality fiasco finale grief hardship havoc ill infliction meltdown misadventure mischance misery misfortune mishap reverse scourge stroke termination the worst tragedy trial trouble upshot waterloo wreck

Antonyms: benefit blessing favor good fortune good luck happiness miracle success wonder